A radiosonde is a small weather sensor package that is typically attached to a weather balloon. As it rises into the atmosphere it measures parameters such as temperature, humidity, pressure, GPS location etc, and transmits this data back down to a receiver base station using a radio signal.
Zilog's RS is a free open source radiosonde decoder for Linux and it supports a wide range of radiosonde protocols. Together with an RTL-SDR it is possible to receive radiosonde signals, and decode them using RS.
Over on his website, happysat has recently uploaded a tutorial that shows how to use RS with an RTL-SDR, CubicSDR or GQRX, and FoxtrotGPS, a GPS plotting program for visualizing the location of the radiosonde. The tutorial covers some tricky points like setting up audio piping in Linux, and getting the GPS data into a virtual COM port to use with FoxtrotGPS.
Alternatively, there are also Windows GUI based sonde decoders that can be used with the RTL-SDR such as SondeMonitor which costs 25 Euros, but also covers a wide range of sonde protocols, and RS41 Decoder which is a GUI for the RS41 sonde protocol only. If you are interested we have a tutorial on setting up radiosonde decoding in Windows with SondeMonitor available here.